Alterations in renal tubular phosphate transport during intravenous infusion of parathyroid extract in the dog

¹ Department of Pharmacology, University of British Columbia, Vancouver, Canada

The intravenous infusion of parathyriod extract at an adequate rate (1–4 u/kg/hr.) invariably leads to phosphaturia which is primarily the result of altered renal tubular transport of the ion. In the intact fasted dog, several hours may be required for the infusion of parathyroid extract to reduce the initially high threshold for endogenous phosphate excretion below the filtered phosphate load. Other procedures which reduce the threshold for phosphate excretion may accelerate the onset of phosphaturia under these circumstances. However, the sluggish nature of this response suggests that parathyroid hormone does not contribute to the rapid adjustments in renal tubular phosphate transport which accelerate phosphate excretion following phosphate administration.

This article has been cited by other articles:

				S. G. Massry, R. M. Friedler, and J. W. Coburn Excretion of Phosphate and Calcium: Physiology of Their Renal Handling and Relation to Clinical Medicine Arch Intern Med, June 1, 1973; 131(6): 828 - 859. [Abstract] [PDF]