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Am J Physiol 196: 340-342, 1959;
0002-9513/59 $5.00
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Effect of anesthetic agents on spinal cord of cat

Clark T. Randt 1 and William F. Collins 1

1 Divisions of Neurology and Neurosurgery, Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio

Somatic evoked responses in the dorsal column and anterolateral column of the cervical spinal cord in 14 cats are shown to have differential susceptibility to anesthetic agents. Nitrous oxide, cyclopropane and Nembutal have more effect on the postsynaptic anterolateral column potentials than on the larger fiber presynaptic dorsal column or postsynaptic medial lemniscus responses. The results corroborate the previous evidence indicating greater susceptibility of small fiber afferent systems to anesthetic agents.

Submitted on August 6, 1958






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