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Am J Physiol 196: 311-314, 1959;
0002-9513/59 $5.00
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A method for simultaneous catheterization of major hepatic vessels in a chronic canine preparation

William C. Shoemaker 1, William F. Walker 1, Theodore B. Van Itallie 1, and Francis D. Moore 1

1 Department of Surgery, Harvard Medical School and Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts

A feasible method for measuring concentration changes of various substances as they enter and leave the liver is described together with the operative technique. This preparation allows simultaneous sampling of blood from all major hepatic vessels in the in vivo, unanesthetized dog under chronic experimental conditions. A modification of this technique is described whereby liver biopsies may be obtained at the same time as the blood sampling.

Submitted on May 21, 1958






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