Effect of Feeding Protein and Urea on Renal Concentrating Ability in the Rat

¹ From the Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut

Maximum urinary concentration, achieved after dehydration or after administration of vasopressin, was significantly higher in rats prefed for 3 days on a 40% protein diet, or a 10% protein, 10% urea diet, than in the same rats fed an isocaloric diet containing 10% protein. The effect of protein in enhancing renal concentrating ability was slightly but significantly greater than that of an isonitrogenous quantity of urea. The solute concentration of urine excreted after large amounts of exogenous vasopressin was not as high as that reached after dehydration alone.

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