Cardiac Hypertrophy in Rats and Mice Given 3, 3', 5-Triiodo-L-Thyronine Orally

¹ From the Department of Pharmacology, School of Medicine, University of Virginia, Charlottesville, Virginia

The giving of 3,3',5-triiodo-l-thyronine in the drinking water produces marked metabolic and circulatory changes. These effects produce hypertrophy of the heart. The water content of the hypertrophied hearts does not change. The hypertrophy of the heart is obtained in both rats and mice. In the rat, following removal of the T-3, there is a return of the heart to approximately the normal size.