Effects of Ascites Formation on Response to Rapid Water, Sodium and Dextran Loads in Intact and Diabetes Insipidus Ringer's-Infused Dogs

¹ From the Cardiovascular Department, Medical Research Institute, Michael Reese Hospital, Chicago, Illinois

The ascitic Ringer's-infused dog exhibits a qualitatively normal diuretic response to rapid intravascular injection of Ringer's solution, glucose-in-water and dextran-in-water. This finding indicates that receptor-effector arcs for sensing and disposing of ingested fluid loads are intact and operative in the ascitic animal, but ordinarily fail of adequate stimulation because of the hemodynamic aberration leading to depletion of effective circulating fluids. The production of gross ascites and fluid retention in the diabetes insipidus dog demonstrates that the hypothalamic-posterior pituitary antidiuretic system is not an essential prerequisite for edema formation.

Note:
With the Assistance of A. Ellis, C. Kakita and A. Rosen