Gastric Secretion in the Mouse

¹ From the Department of Gastro-Intestinal Research, Medical Research Institute of Michael Reese Hospital, Chicago, Illinois

The basal and stimulated gastric secretion of unanesthetized Holtzman substrain of Rockland RAP white Swiss male mice was investigated. Intubation of the stomach with a plastic tube yielded low values of secretion and acidity due to irritation and mucus production in the stomach. Simple ligation of the pylorus demonstrated that the mouse has a constant basal secretion. Histamine stimulated acid production only when employed in very large doses. Best results were obtained when 0.7 mg of histamine dihydrochloride/gm of body weight (70 mg/kg) was injected subcutaneously. Experiments with ligated pylorus of more than 6-hour duration demonstrated lower acidities, and 24-hour experiments showed no free acid, low total acidity and pH near neutrality.

This article has been cited by other articles:

				N. McDaniel, A. J. Pace, S. Spiegel, R. Engelhardt, B. H. Koller, U. Seidler, and C. Lytle Role of Na-K-2Cl cotransporter-1 in gastric secretion of nonacidic fluid and pepsinogen Am J Physiol Gastrointest Liver Physiol, September 1, 2005; 289(3): G550 - G560. [Abstract] [Full Text] [PDF]