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Am J Physiol 194: 229-235, 1958;
0002-9513/58 $5.00
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Renal Conservation of Trimethylamine Oxide by the Spiny Dogfish, Squalus Acanthias

Julius J. Cohen 1, Marcus A. Krupp 1, and Charles A. Chidsey III 1

1 From the Department of Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio and the Mount Desert Island Biological Laboratory, Salisbury Cove, Maine

Trimethylamine oxide (Oxide) plasma concentrations in the dogfish have been found to be maintained within the narrow range of 60–80 µmol/ml. These levels are maintained in spite of prolonged (up to 41 days) fasting. The Oxide is freely filterable at the glomerulus but is avidly reabsorbed by the renal tubule. Thus, less than 10% of the filtered Oxide appears in the urine. Dogfish urine has been found to contain an unidentified volatile amine, not NH3, presumed to be trimethylamine. The possible role of the Oxide in elasmobranch physiology is discussed.

Submitted on January 21, 1958




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Maintenance and accumulation of trimethylamine oxide by winter skate (Leucoraja ocellata): reliance on low whole animal losses rather than synthesis
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2006; 291(6): R1790 - R1798.
[Abstract] [Full Text] [PDF]


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