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1 From the Laboratories of Neurochemistry and Neurophysiology, National Institute of Neurological Diseases and Blindness, National Institutes of Health, Bethesda, Maryland
An improved method for injection of chemicals into the squid giant axon is described. A large number of metabolically active materials were found to be without any effect upon the action potential. Tetraethylammonium chloride produced a striking prolongation of the action potential. Cocaine and ethanol caused a transient reduction in the amplitude of the action potential. A filter paper eluate was found to contain materials which caused repetitive firing followed by a reduction in amplitude of the action potential and finally inexcitability.
Submitted on November 5, 1957
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