| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 From the Department of Physiology, State University of New York, Downstate Medical Center at New York City, Brooklyn, New York
Simultaneous records of the transmembrane potential from two points in a single cardiac fiber indicate that during the refractory period when repolarization is about half complete graded responses appear close to the site of stimulation. These responses to cathodal pulses vary in amplitude with stimulus intensity and may show spatial decrement even when an overshoot is present close to the stimulating electrode. The results obtained indicate that the transition from graded to all-or-none response does not depend solely on the restoration of membrane potential. In some experiments stimulation was accomplished by employing one lumen of a double microelectrode; in others single Purkinje fibers were stimulated by action potentials propagated from attached papillary muscle. Similar graded responses were elicited in both instances. The experiments employing propagating action potentials as stimuli suggest the possible occurrence of graded activity as a response mechanism in the intact heart.
Submitted on October 7, 1957
This article has been cited by other articles:
|
|
 |
|
  M. G. Chang, Y. Zhang, C. Y. Chang, L. Xu, R. Emokpae, L. Tung, E. Marban, and M. R. Abraham Spiral Waves and Reentry Dynamics in an In Vitro Model of the Healed Infarct Border Zone Circ. Res., November 20, 2009; 105(11): 1062 - 1071. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G.-S. Hwang, L. Tang, B. Joung, N. Morita, H. Hayashi, H. S. Karagueuzian, J. N. Weiss, S.-F. Lin, and P.-S. Chen Superiority of Biphasic Over Monophasic Defibrillation Shocks Is Attributable to Less Intracellular Calcium Transient Heterogeneity J. Am. Coll. Cardiol., September 2, 2008; 52(10): 828 - 835. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Y. Sidorov, M. C. Woods, and F. Baudenbacher Cathodal stimulation in the recovery phase of a propagating planar wave in the rabbit heart reveals four stimulation mechanisms J. Physiol., August 15, 2007; 583(1): 237 - 250. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Y. Sidorov, M. C. Woods, P. Baudenbacher, and F. Baudenbacher Examination of stimulation mechanism and strength-interval curve in cardiac tissue Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2602 - H2615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J Workman, K. A Kane, and A. C Rankin Characterisation of the Na, K pump current in atrial cells from patients with and without chronic atrial fibrillation Cardiovasc Res, September 1, 2003; 59(3): 593 - 602. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yashima, Y.-H. Kim, S. Armin, T.-J. Wu, Y. Miyauchi, W. J. Mandel, P.-S. Chen, and H. S. Karagueuzian On the mechanism of the probabilistic nature of ventricular defibrillation threshold Am J Physiol Heart Circ Physiol, January 1, 2003; 284(1): H249 - H255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. F Hoffman And then came the microelectrode Cardiovasc Res, January 1, 2002; 53(1): 1 - 5. [Full Text] [PDF]
|
|
|
|
|
|
H. S Karagueuzian and P.-S. Chen Cellular mechanism of reentry induced by a strong electrical stimulus: Implications for fibrillation and defibrillation Cardiovasc Res, May 1, 2001; 50(2): 251 - 262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Moubarak, P. E. Karasik, R. D. Fletcher, and M. R. Franz High dispersion of ventricular repolarization after an implantable defibrillator shock predicts induction of ventricular fibrillation as well as unsuccessful defibrillation J. Am. Coll. Cardiol., February 1, 2000; 35(2): 422 - 427. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
