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Am J Physiol 193: 83-85, 1958;
0002-9513/58 $5.00
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Nonconcentration of Thiocyanate-C14 by the Thyroid Gland of the Mouse

Seymour H. Wollman 1, James C. Reid 1, and Franklin E. Reed 1

1 From the Laboratory of Physiology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

After administration of C14-labeled thiocyanate, the concentration of C14 in the thyroid gland following equilibration was about half that in the serum of normal and hypophysectomized C3H mice. Paper chromatography of the serum revealed that 90% of the C14 was in the form of thiocyanate. These results, coupled with a previous analysis which indicated that thiocyanate competitively inhibited the thyroid iodide concentrating mechanism, appear to eliminate the possibility that concentrated iodide is held in the thyroid by adsorption.

Submitted on October 17, 1957







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