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Am J Physiol 193: 4-8, 1958;
0002-9513/58 $5.00
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Gastric Contractions in the Rat

Seoras D. Morrison 1, Hsiang Ju Lin 1, Helen E. Eckel 1, Theodore B. Van Itallie 1, and Jean Mayer 1

1 From the Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts

A method is described for continuous recording of gastric concentrations in the normal rat. Fasting concentrations normally show a cyclical behavior with a period of 15–20 minutes. These concentrations are inhibited by instillation of many substances into the stomach via a permanent gastric fistula, the duration of the inhibition varying with volume and concentration. Neither glucose nor insulin given i.v. affects the fasting contractions; however, 0.1 mg of intravenous glucagon invariably produces complete inhibition of contractions for 4–7 minutes.

Submitted on September 27, 1957






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