Regional Blood Flow by Fractional Distribution of Indicators

¹ From the Department of Physiology, The Ohio State University College of Medicine, Columbus, Ohio

K⁴² Cl, Rb⁸⁶Cl and iodoantipyrine (I¹³¹) were given in single intravenous injections to rats. The isotope content of the organs and the arterial blood concentrations were studied as a function of time. K⁴²Cl and Rb⁸⁶Cl reached a stable level in all organs other than the brain in 6–9 seconds and maintained this level until 64 seconds. The arterial concentration curves for the isotopes showed that the injected dose was almost completely transferred into the arterial system at about 6–8 seconds. The isotopes showed subsequent recirculation amounting to about 40% of the original dose between the first recirculation and 64 seconds. The organs which displayed stability during the period of recirculation must have had extraction ratios from zero time less than 1.00 but equal to that of the whole body. The fractional uptake of indicator by such organs must therefore have been equal to their blood flow fraction of the cardiac output. The brain reached its maximum content of Rb⁸⁶ and K⁴² in 5–6 seconds; both isotopes then disappeared rapidly. The brain was thus shown to have a lower extraction ratio toward these isotopes than the body as a whole; its flow fraction could not therefore be measured by their use. Most organs failed to show stability of their iodoantipyrine content between 9 and 64 seconds; this indicator is not suitable for the measurement of the flow fraction of such organs. By combining values for the cardiac output and the fractional uptake of K⁴² in dog organs, regional blood flow values were obtained. For those other organs where flow values by other methods are available, the agreement was good. The following blood flow values were obtained in the major organs of the dog: Heart (coronary flow), 1.0 ml/gm/min.; kidney, 3.0 ml/gm/min.; liver, 1.2 ml/gm/min. (0.4 ml/gm/min. hepatic artery, 0.8 ml/gm/min. portal vein); skin, 0.07 ml/gm/min.

This article has been cited by other articles:

				H. W. Strauss Stress Myocardial Perfusion Imaging-- The Beginning... J. Am. Coll. Cardiol. Img., March 1, 2008; 1(2): 238 - 240. [Full Text] [PDF]

				Y. S. Lew, A. Kolozsvary, S. L. Brown, and J. H. Kim Synergistic Interaction with Arsenic Trioxide and Fractionated Radiation in Locally Advanced Murine Tumor Cancer Res., August 1, 2002; 62(15): 4202 - 4205. [Abstract] [Full Text] [PDF]

				Yuefei Liu, J. M. Steinacker, A. Opitz-Gress, M. Clausen, and M. Stauch Comparison of whole-Body Thallium Imaging with Transcutaneous PO2 in Studying Regional Blood Supply in Patients with Peripheral Arterial Occlusive Disease Angiology, September 1, 1996; 47(9): 879 - 886. [Abstract] [PDF]

				P. M. Kirshbom, L. R. Skaryak, L. R. DiBernardo, F. H. Kern, W. J. Greeley, J. W. Gaynor, and R. M. Ungerleider pH-STAT COOLING IMPROVES CEREBRAL METABOLIC RECOVERY AFTER CIRCULATORY ARREST IN A PIGLET MODEL OF AORTOPULMONARY COLLATERALS J. Thorac. Cardiovasc. Surg., January 1, 1996; 111(1): 147 - 157. [Abstract] [Full Text]

				S. Bondy and M. Harrington Brain blood flow: alteration by prior exposure to a learned task Science, January 20, 1978; 199(4326): 318 - 319. [Abstract] [PDF]

				W. H. Oldendorf, S. Hyman, L. Braun, and S. Z. Oldendorf Blood-Brain Barrier: Penetration of Morphine, Codeine, Heroin, and Methadone after Carotid Injection Science, December 1, 1972; 178(4064): 984 - 986. [Abstract] [PDF]

				A. W. Richardson, T. Cooper, and T. Pinakatt Thermodilution Method for Measuring Cardiac Output of Rats by Using a Transistor Bridge Science, January 26, 1962; 135(3500): 317 - 318. [Abstract] [PDF]