Enhancement of Phosphatide-Induced Hypercholesteremia by Prior Ingestion of Cholesterol and Triglyceride

¹ From the Harold Brunn Institute, Mount Zion Hospital, San Francisco, California

Rats fed stock diet enriched with 2% cottonseed oil and 2% cholesterol for 3 days prior to intravenous infusion with phosphatides showed a hypercholesteremic response to the infusion which was significantly greater than that of rats fed a diet enriched in cottonseed oil only. The latter animals showed the same hypercholesteremic response as rats maintained on a fat and sterol-free diet. During infusions, the average plasma phospholipid concentrations of the three groups was the same.

Note:
with the technical assistance of Betty Tsai, Clarence Omoto and Warren Hayashi

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