Respiratory Studies on the Utilization of Carbohydrate After Adrenalectomy

¹ From the Departments of Physiology and Internal Medicine, Yale University School of Medicine, New Haven, Connecticut
² From the Department of Physiology and Internal Medicine, Yale University School of Medicine, New Haven, Connecticut

Respiratory quotients and C¹⁴O₂ production from 2-C¹⁴ pyruvate were studied in normal and adrenalectomized rats following subcutaneous epinephrine as a carbohydrate mobilizing agent. The adrenalectomized rats responded with a rise in R.Q. that was greater and more prolonged than that of the controls. They also expired more C¹⁴O₂ than did the normal animals during the 4-hour period of study. These data are consistent with an increased rate of oxidation of carbohydrate by the adrenalectomized animal rather than increased lipogenesis.