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Am J Physiol 190: 252-254, 1957;
0002-9513/57 $5.00
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Effects of Gastroenterostomy and of Pyrogen on Mann-Williamson Ulcer

H. Necheles 1, M. R. Gordon 1, H. Gaspar 1, and L. Walker 1

1 From the Department of Gastro-Intestinal Research, Medical Research Institute, Michael Reese Hospital, Chicago, Illinois

Dogs were subjected to the Mann-Williamson operation. Twenty-two controls had a mean survival rate of 95 days, and all had gastric or jejunal ulcers. In 12 dogs with the Mann-Williamson operation and simultaneous gastroenterostomy, the mean survival rate was 56 days, and gastric or jejunal ulcers were found in all. Fourteen dogs with the Mann-Williamson operation, treated with Piromen, had a mean survival time of 117 days, and ulcers were found in most animals. The questions of the jet theory of ulcer formation, nutritional deficiency, and suture line ulcer in the Mann-Williamson preparation are discussed.

Submitted on March 24, 1957






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