AJP Legacy AJP: Heart and Circulatory Physiology
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Am J Physiol 190: 8-12, 1957;
0002-9513/57 $5.00
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Phospholipid Antithromboplastin

Assay in Vitro and Evaluation in Vivo of Purified Fractions

M. J. Silver 1, D. L. Turner 1, and L. M. Tocantins 1

1 From the Charlotte Drake Cardeza Foundation, Jefferson Medical College, Philadelphia, Pennsylvania

The anticoagulant activity of brain phosphatide fractions may be assayed using sodium desoxycholate which produces water clear preparations instead of emulsions. The purified phosphatide fractions studied are neither toxic, nor pyrogenic and produce an elevated and lasting increase in the clotting time of blood, when administered intravenously to dogs.

Submitted on February 12, 1957






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