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Am J Physiol 190: 180-182, 1957;
0002-9513/57 $5.00
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Lipid and Cholesterol Content of Hepatic Lymph in Experimental Nephrosis

Meyer Friedman 1, Ray H. Rosenman 1, and Sanford O. Byers 1

1 From the Harold Brunn Institute, Mount Zion Hospital, San Francisco, California

The lipid and cholesterol content of hepatic lymph, a diffusate of plasma, was determined in nephrotic rats during both the induction and the developed stages of experimental nephrosis. Despite the occurrence of hypercholesteremia and hyperlipemia in such rats, their hepatic lymph was found to contain a normal content of cholesterol and a greatly reduced content of total lipid. These results suggest that in the nephrotic state an intravascular alteration occurs in the various lipid fractions of plasma that interfere with their normal rate of egress from plasma.

Submitted on January 15, 1957




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