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Am J Physiol 190: 142-146, 1957;
0002-9513/57 $5.00
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Effect of Certain Steroids on Metabolic Rate of Hyperthyroid Rats

R. J. Doisy 1 and H. A. Lardy 1

1 From the Institute for Enzyme Research and Department of Biochemistry, University of Wisconsin, Madison, Wisconsin

The effects of certain steroids on the elevated basal metabolic rate (BMR) associated with thyrotoxicosis were investigated. Under our experimental conditions the adrenal cortical hormones had no effect, whereas large doses of estrogenic hormones caused marked depressions of the elevated BMR of hyperthyroid male rats. This antagonism to the calorigenic action of the thyroid hormones was demonstrable also in adrenalectomized and adrenalectomized-thyroidectomized rats. It would appear that this antagonism between the estrogenic and thyroid hormones is not mediated via the pituitary, adrenal or thyroid glands.

Submitted on February 14, 1957






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