Renal Functions in the Chimpanzee

¹ From the Department of Surgical Physiology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C.

The excretion of creatinine and para-aminohippurate in five chimpanzees was found to be both by glomerular filtration and tubular secretion with mutual interference between the secretory processes. No evidence was found to suggest that inulin is subject to tubular secretion or reabsorption and it is therefore still acceptable for the measurement of glomerular filtration. The absolute values of glomerular filtration and renal excretion of creatinine and para-aminohippurate may have been modified by the use of anesthesia, but no striking differences are apparent between the kidney of the chimpanzee and that of man. PAH at high plasma concentration increases the excretion of potassium.