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Am J Physiol 189: 548-550, 1957;
0002-9513/57 $5.00
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Renal Metabolism of 5-Hydroxyindolacetic Acid

Agamemnon Despopoulos 1 and Herbert Weissbach 1

1 From the Clinic of General Medicine and Experimental Therapeutics and the Laboratory of Clinical Biochemistry, National Heart Institute, National Institutes of Health, Bethesda, Maryland

Slices of rabbit kidney cortex concentrate 5-hydroxyindolacetic acid by an active aerobic process. The accumulation of 5-hydroxyindolacetic acid can be increased by acetate ion and decreased by dinitrophenol. In patients with malignant carcinoid, the excretion of the indole can be decreased by the intravenous administration of probenecid. These data suggest that the renal elimination of 5-hydroxyindolacetic acid, like that of p-aminohippuric acid, is achieved by glomerular filtration and active tubular excretion.

Note:
with the technical assistance of Diana Redd and Colette Robillard

Submitted on February 12, 1957






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