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Am J Physiol 189: 105-107, 1957;
0002-9513/57 $5.00
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Effect of Adenosine on Phosphofructokinase Activity of Preserved Blood

Y. S. Brownstone 1 and M. C. Blanchaer 1

1 From the Department of Biochemistry, St. Boniface Hospital, and the Department of Physiology and Medical Research, University of Manitoba, Winnipeg, Manitoba, Canada

Adenosine in concentrations of 5–20 mm prevents the progressive decrease in activity of the erythrocyte glycolytic enzyme phosphofructokinase in blood preserved in acid citrate-dextrose at 4°. In hemolysates the protective effect of adenosine is also exhibited by its metabolic derivatives inosine, ribose-5-phosphate and adenosine triphosphate. The beneficial effects of adenosine on in vivo survival of stored red cells, glycolysis and PFK activity suggests that the integrity of this enzyme may influence the keeping qualities of ACD preserved blood.

Submitted on September 17, 1956






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Copyright © 1957 by the American Physiological Society.