High-Energy Phosphate Content of Liver Tissue in Experimental Hemorrhagic Shock

Influence of Aureomycin

¹ From the Kirstein Laboratory for Surgical Research, Beth Israel Hospital, and the Department of Surgery, Harvard Medical School, Boston, Massachusetts

The ‘high-energy phosphate’ content of liver tissue declines during the course of hemorrhagic shock in the dog. The degree of decline does not correlate with the loss of responsiveness to transfusion therapy. Phosphate energy stores depleted during hemorrhagic shock are rapidly rebuilt following replacement transfusion. Prior treatment with aureomycin reduces the depletion of phosphate energy stores during hemorrhagic shock. Aureomycin given in the same manner has been found to preserve the dog's responsiveness to transfusion therapy. The protective action of aureomycin in hemorrhagic shock is not attributable to the preservation of phosphate energy stores, however, because the change in these stores does not correlate with responsiveness to blood replacement.

Note:
with the technical assistance of Edward Kalnins