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Am J Physiol 188: 81-85, 1956;
0002-9513/56 $5.00
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Response of Dogs to Long-Term Cholesterol Feeding

Kenneth H. Shull 1 and George V. Mann 1

1 From the Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts

Hypercholesteremias averaging 495 and 570 mg % were maintained in two female dogs for periods of 4 and 3 1/2 years, respectively, by cholesterol feeding. The serum beta-lipoprotein levels were also grossly elevated throughout these periods. Neither the level of fat calories nor the calorie balance appeared to affect significantly these serum lipid levels. Gross and microscopic examinations performed at autopsy on these two dogs failed to reveal any abnormalities in the cardiovascular system or liver.

Submitted on August 1, 1956






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Copyright © 1956 by the American Physiological Society.