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Am J Physiol 187: 571-572, 1956;
0002-9513/56 $5.00
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Influence of Decreased Ambient Oxygen on Susceptibility of Rats to Audiogenic Seizures

Walter G. Mitchell 1 and Fred A. Hitchcock 1

1 From the Laboratory of Aviation Physiology and the Department of Physiology, Ohio State University, Columbus, Ohio

Male Wistar rats were tested for audiogenic seizure susceptibility at various levels of decreased ambient oxygen. At 15.9% and 12.3% oxygen, the number of seizures occurring were approximately the same as the controls. Enhancement of seizure susceptibility occurred at 14.5% ambient oxygen, indicating a preliminary excitatory effect. Oxygen levels of 9.6% and below resulted in inhibition of seizures. The over-all picture was that of a biphasic effect of oxygen lack on audiogenic seizure susceptibility.

Submitted on July 13, 1956






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