Renin Tachyphylaxis and Renal Ischemia in the Cat

¹ From the Department of Physiology, University of Southern California School of Medicine, Los Angeles, California

The production of renin by the completely ischemic cat's kidney was investigated, as well as the relationship of renin to experimental hypertension in the cat. Tachyphylaxis to hog renin abolishes the pressor response following endogenous renin production by the completely ischemic kidney. However, the elevated blood pressure which occurs following partial renal ischemia (renal hypertension) is not reduced after renin tachyphylaxis. It is therefore concluded that the mechanism responsible for the elevation in blood pressure in the two cases is on a qualitatively different basis.