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Am J Physiol 187: 509-514, 1956;
0002-9513/56 $5.00
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Renal and Arterial Effects of Serotonin in the Anesthetized Rat

F. del Greco 1, G. M. C. Masson 1, and A. C. Corcoran 1

1 From the Division of Research, The Cleveland Clinic Foundation, and The Frank E. Bunts Educational Institute, Cleveland, Ohio

Serotonin infused intravenously in anesthetized rats brought into osmotic diuresis with mannitol is antidiuretic in doses of more than 5 µg/kg/ min. This effect is dependent on decreased glomerular filtration and is largely independent of the changes in blood pressure. The renal and arterial pressure effects of serotonin are prevented, but not reversed by intravenously injected lysergic acid diethyl-amide and bromo-lysergic acid diethyl-amide.

Submitted on May 28, 1956




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J. M. GROSS, T. J. BERNDT, and F. G. KNOX
Effect of Serotonin Receptor Antagonist on Phosphate Excretion
J. Am. Soc. Nephrol., June 1, 2000; 11(6): 1002 - 1007.
[Abstract] [Full Text]


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