Influence of Ouabain, Strophanthidin and Dihydrostrophanthidin on Sodium and Potassium Transport in Frog Sartorii

¹ From the Department of Pharmacology, Harvard Medical School, Boston, Massachusetts

Ouabain and strophanthidin at a concentration of about 10^–6 molar appear to inhibit the net transport of sodium out of and of potassium into the cells of the frog sartorius muscle under conditions where transport would otherwise occur. This inhibition occurs without significant effect on the resting potential. Dihydrostrophanthidin, also at a concentration of 10^–6 m, failed to show the inhibitory action displayed by ouabain and strophanthidin.