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Am J Physiol 187: 227-230, 1956;
0002-9513/56 $5.00
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Succinoxidase and Gastric Acid Secretion

Horace W. Davenport 1 and Virginia J. Chavré 1

1 From the Department of Physiology, University of Utah College of Medicine, Salt Lake City, Utah

The participation of succinoxidase in gastric acid secretion and in renal transport of p-aminohippurate (PAH) was studied in mice and frogs using antimycin A and sodium malonate as inhibitors. Antimycin A inhibits both gastric acid secretion and renal PAH accumulation in both species in vitro, but when given intraperitoneally it inhibits acid secretion and PAH accumulation in the frog but neither function in the mouse. Malonate given subcutaneously inhibits renal PAH accumulation in both species but has no effect on gastric acid secretion. The effect of antimycin A is interpreted in terms of inhibition of electron transport systems essential for acid secretion, and the failure of malonate to affect acid secretion is not taken to be conclusive evidence of the absence of participation of succinic dehydrogenase.

Submitted on May 25, 1956






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