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Am J Physiol 186: 554-556, 1956;
0002-9513/56 $5.00
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Effect of Intravenous Iron in Experimental Traumatic Shock

Donn L. Smith 1, Irvin I. Kibbey 1, Max E. Bierwagen 1, and J. R. Cruse 1

1 From the Department of Pharmacology, University of Colorado School of Medicine, Denver, Colorado

Intravenous administration of colloidal saccharated iron oxide prior to intestinal traumatization in the albino rat resulted in a significant reduction of the mean survival time. Sodium gold thiosulfate and colloidal manganese hydroxide employed in the same manner did not significantly alter mean survival times. ACTH and cortisone did not modify the deleterious effects of iron in experimental traumatic shock. A decrease in soluble liver iron was observed when traumatization followed the injection of iron. It was concluded that the reduction of mean survival time in iron injected, traumatized animals was due to a specific action of iron and is not the result of generalized heavy metal toxicity.

Submitted on March 25, 1956






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