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Am J Physiol 186: 525-528, 1956;
0002-9513/56 $5.00
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Cardiovascular Effects of Chlorpromazine in the Dog

G. B. Spurr 1, Steven M. Horvath 1, and Enid Allbaugh Farrand 1

1 From the Department of Physiology and the Cardiovascular Laboratory, State University of Iowa College of Medicine, Iowa City, Iowa

Chlorpromazine in doses of 2 and 5 mg/kg has been found to produce an initial hypotension in anesthetized dogs which was followed by return of the mean arterial blood pressure to near control levels. During the next 60–65 minutes there was a secondary decline in the pressure to hypotensive levels. Both an initial and secondary hypotension were the result of a decrease in peripheral vascular resistance.

Submitted on March 11, 1956




This article has been cited by other articles:


Home page
 Arch Intern MedHome page
N. M. KAPLAN
Hypotension as a Complication of Promazine Therapy
Arch Intern Med, February 1, 1959; 103(2): 219 - 223.
[Abstract] [PDF]


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