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Am J Physiol 186: 501-504, 1956;
0002-9513/56 $5.00
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Factors Influencing Alveolar-Arterial Oxygen Pressure Gradient

Effect of Ventilation and Alveolar Oxygen Tension

Robert J. Atwell 1, Joseph F. Tomashefski 1, and Joseph M. Ryan 1

1 From the Ohio Tuberculosis Hospital and the Department of Medicine, The Ohio State University, Columbus, Ohio

The A-a oxygen pressure gradient was determined in anesthetized dogs. Data obtained when pulmonary ventilation and alveolar oxygen tension are varied independently suggests that: a) the magnitude of the A-a oxygen pressure gradient correlates directly with the Paoo2. b) In the anesthetized dog venous admixture seems to be constant, unrelated to the changes in ventilation produced by positive-negative pressure breathing. c) Venous admixture is the most important factor in producing the A-a gradient in the dog.

Submitted on October 6, 1955






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