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1 From the Department of Physiology, School of Medicine, University of California, Berkeley, California
In order to determine quantitatively the participation of the spleen and the bone marrow separately, five groups of splenectomized and non-splenectomized mice totalling 87 individuals were exposed to a simulated altitude of 15,000 feet continuously for periods of 30–58 days. RBC counts and hematocrit determinations were made at various intervals. It was found that about two-fifths of the increase in red cells could be referred to a tonic contraction of the spleen and the remaining three-fifths to the production of red cells by the bone marrow.
Submitted on February 22, 1956
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