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Am J Physiol 186: 299-303, 1956;
0002-9513/56 $5.00
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Positive Chronotropic Effect of Increasing Right Atrial Pressure in the Isolated Mammalian Heart

John R. Blinks 1

1 From the Department of Pharmacology, Harvard Medical School, Boston, Massachusetts

Effect of increasing right atrial pressure on the rate of the mammalian heart was studied in the isolated dog heart and in an isolated atrium preparation of the rabbit. It was shown that increases in right atrial pressure may increase the heart rate by more than 50%. The rabbit atrium is sensitive to a rise in pressure from 0 to 25 mm of water; a maximal rate response can be elicited by a pressure of about 100 mm of water. Local anesthetics in nontoxic concentrations, tetraethylammonium ion, and veratramine have no consistent effect upon the pressure response. It is suggested that mechanical tension may exert a direct stimulatory influence upon pacemaker tissues in general.

Submitted on January 19, 1956




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