Effect of an Histaminase Inhibitor (Aminoguanidine) on the Gastric Secretory Response to Exogenous Histamine

¹ From the Department of Clinical Science, University of Illinois College of Medicine, Chicago, Illinois

Aminoguanidine, a diamine oxidase inhibitor, in a dose of 0.4–1.0 mg/kg/ min. given intravenously during a period of from 20–25 minutes stimulates the gastric acid secretory mechanism of a Heidenhain and Ivy pouch dog secreting no free acid after a latent period of from 20–30 minutes for a period of 1–4 hours, depending on the dose. A rough dose-response relationship exists until evidences of toxicity occur at a dose of 4–5 mg/kg/min. is given. The administration of an intravenous threshold dose of aminoguanidine decidedly augments the gastric secretory response to a 0.05-mg dose of histamine diphosphate given subcutaneously to such dogs every 10 minutes. The existing evidence suggests that the augmentory effect is an additive effect due to the accumulation of histamine resulting from the action of aminoguanidine on histaminase.