Fatty Acid Utilization by Adrenalectomized Rats

¹ From the Department of Physiology and Medical Research, University of Manitoba, Winnipeg, Canada

The production of radioactive CO₂ by intact and adrenalectomized rats given 1 C¹⁴ octanoic acid and the production of radioactive CO₂ and radioactive acetoacetic acid by surviving liver slices from adrenalectomized and unoperated rats using 1 C¹⁴ octanoic acid as substrate have been studied. It was found that the CO₂ production and acetoacetic acid production in vitro and CO₂ production in vivo did not differ in the two types of animals. These results suggest that the adrenalectomized rat does not utilize fatty acids at a higher than normal rate and that the previously reported decreased incorporation of acetate into fatty acids by the liver slices from adrenalectomized rats is a reflection of decreased hepatic lipogenesis.

This article has been cited by other articles:

				F. L. ENGEL The Influence of the Endocrine Glands on Fatty Acid and Ketone Body Metabolism Arch Intern Med, July 1, 1957; 100(1): 18 - 33. [Abstract] [PDF]