Effect of Norepinephrine on Circulation of the Dog in Hemorrhagic Shock

¹ From the Kirstein Laboratory for Surgical Research, Beth Israel Hospital and the Department of Surgery, Harvard Medical School, Boston, Massachusetts

Norepinephrine infusion did not prolong the survival or effect the recovery of dogs in hemorrhagic shock unresponsive to replacement transfusion. During its pressor action in shock, either before or after replacement transfusion, norepinephrine infusion increased coronary, cerebral and adrenal blood flow, reduced renal blood flow, and did not change hepatic blood flow. Cardiac output was increased in oligemic shock but not after blood replacement. Pulmonary arterial pressure and right and left auricular pressures were raised by norepinephrine infusion in all phases of hemorrhagic shock, and calculated pulmonary vascular resistance was reduced.

Note:
with the technical assistance of Dorothy Kaufman