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Am J Physiol 186: 172-174, 1956;
0002-9513/56 $5.00
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Kidney Function in the Adult Rat

Julian Jacobs 1 and J. H. U. Brown 1

1 From the Department of Physiology, Emory University, Emory University, Georgia

Endogenous creatinine clearance of the adult rat has been determined to be 0.556 ml/min/100 gm B. W. This value must be increased about 25% in order to obtain ‘true’ creatinine clearances. Large doses of atropine or hexamethonium decreased the creatinine, sodium and potassium clearances. The clearance of sodium was decreased to a greater extent than was the creatinine or potassium clearance. The urinary Na/K ratio was also decreased in the presence of both drugs.

Submitted on December 15, 1955






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