Role of Hyperphospholipidemia and Neutral Fat Increase in Plasma in the Pathogenesis of Hypercholesteremia

¹ From the Harold Brunn Institute for Cardiovascular Research, Mount Zion Hospital, San Francisco, California

The induction of a continuous state of hyperphospholipidemia in rats by the infusion of an emulsion of commercially pure soybean phosphatides quickly led to a rise in the plasma cholesterol of the animals. The degree of this rise moreover appeared to be directly dependent upon either the amount of phosphatides injected or the rise in plasma phospholipid occasioned by the injected phosphatides. The hypercholesteremia induced in this fashion was not affected by diversion of the animal's own intestinally derived cholesterol. A similar but less constantly induced hypercholesteremia also was observed to occur soon after the continuous injection of either a saturated or unsaturated type of neutral fat. Although such injection of fat also led to a rise in plasma phospholipid, this latter rise did not appear to be totally responsible for the hypercholesteremia induced. The results suggest not only that hypercholesteremia may be induced by experimental elevation of either plasma phospholipid or neutral fat but also that the hyperlipemia observed in various hypercholesteremic states may be involved in the latter's pathogenesis.

Note:
with the technical assistance of Clarence Omoto and Warren Hayashi

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