Biosynthesis of Fatty Acids in Liver and Intestine of Intact Normal, Fasted and X-Irradiated Rats

¹ From the Departments of Biochemistry and Radiology, Vanderbilt University School of Medicine, Nashville, Tennessee

A 72-hour fasting period affects intestinal incorporation of C¹⁴-acetate into fatty acids to a smaller extent that it does hepatic incorporation. Glycogen concentration and hepatic incorporation of acetate into fatty acids increases in irradiated, fasted rats (750 r total-body x-irradiation) compared to fasted controls. Intestinal incorporation of C¹⁴-acetate into fatty acids decreases in the irradiated rat. A direct relationship between the amount of liver glycogen present and the amount of incorporation of C¹⁴ into fatty acids was not observed at these levels of hepatic glycogen and lipogenesis.

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