Renal Tubular Reabsorption of Inorganic Sulfate in the Dog, as Affected by Glomerular Filtration Rate and Sodium Chloride

¹ From the Department of Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio

The sulfate Tm varies in the dog directly with the glomerular filtration rate. Sulfate Tm is markedly depressed by the intravenous injection of as little as 0.1 gm sodium chloride/kg body weight. Maximum depression is obtained first 50 minutes after the injection. Xylose, urea and mannitol have no effect on sulfate Tm. The effect of sodium chloride is therefore not due to an osmotic action, but seems to depend on an increased level of sodium or chloride ions in the glomerular filtrate.