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Am J Physiol 185: 505-509, 1956;
0002-9513/56 $5.00
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Effect of Chlorpromazine on Survival From a Single Massive Hemorrhage

Steven M. Horvath 1, G. B. Spurr 1, and C. Blatteis 1

1 From the Department of Physiology and the Cardiovascular Laboratory, State University of Iowa, College of Medicine, Iowa City, Iowa

In dogs subjected to a single hemorrhage equivalent to 4% of the body weight, 2 and 5-mg/kg doses of chlorpromazine administered 30 minutes before hemorrhage and 2 mg/kg given immediately after hemorrhage exerted a deleterious effect in terms of survival. When the drug was given 5 hours before hemorrhage no injurious effect on survival was observed. The reduced frequency of survival appeared to be related to the autonomic blocking activity of the chlorpromazine.

Submitted on January 18, 1956




This article has been cited by other articles:


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N. M. KAPLAN
Hypotension as a Complication of Promazine Therapy
Arch Intern Med, February 1, 1959; 103(2): 219 - 223.
[Abstract] [PDF]


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