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Am J Physiol 184: 575-581, 1956;
0002-9513/56 $5.00
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Metabolism of Isotopic Lactate by the Isolated Dog Heart

H. Mead Cavert 1 and John A. Johnson 1

1 From the Department of Physiology, Medical School, University of Minnesota, Minneapolis, Minnesota

Two aspects of the metabolism of carboxyl-C13-lactate and of alpha-, beta-C13-lactate were investigated in the completely isolated dog heart perfused with heparinized, oxygenated, autogenous blood. Approximately 20% of the respired CO2 was derived from administered lactate (racemic). The extent of conversion of the carboxyl carbon to CO2 was about 70% greater than that of the average of the noncarboxyl carbons. Analysis of cardiac glycogen following the perfusion failed to reveal significant C13 labeling.

Submitted on September 12, 1955






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