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Am J Physiol 184: 415-417, 1956;
0002-9513/56 $5.00
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In Vivo Effect of Heparin on Acid and Alkaline Ribonuclease Activities of Mouse Liver

Gaston De Lamirande 1, George Weber 1, and Antonio Cantero 1

1 From the Montreal Cancer Institute, Research Laboratories, Notre-Dame Hospital, Montreal, Canada

A single dose of 30 µg/gm body weight of depo-heparin was injected subcutaneously into white Swiss mice. At 1, 3, 6 and 12 hours after the injection, the blood coagulation time was measured and the activity of acid and alkaline ribonuclease of liver was determined. This single injection of depo-heparin significantly inhibited the acid and alkaline ribonucleases of liver 1 hour after injection. The enzymatic activities significantly increased after the blood coagulability was restored. The in vivo inhibition of acid and alkaline ribonuclease activity supports the explanation that the accumulation of ribonucleic acid in cells of tissue culture in the presence of heparin might be due to the inhibition of ribonuclease.

Submitted on July 1, 1955






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