Adaptations to Intraperitoneal Sucrose Solutions in the Rat

¹ From the Department of Physiology, The University of Rochester School of Medicine and Dentistry, Rochester, New York

Rats injected intraperitoneally with sucrose solution (1.5 m) two or more times at weekly intervals adapt by increasing the concentration of sucrose in the urine at 1–3 hours and by increasing urine output at the end of 6 hours. The adaptation appears within 2 days after the first injection and disappears after 13 days of no injections. There is no adaptation in absorption from the peritoneal cavity. The adaptation in excretion may therefore be the result of reduced tubular reabsorption of sucrose. Adaptations were observed also in drinking responses and in survival when toxic doses were administered.