Effects of Anorexia and X-Irradiation on Vitamin B₆ Excretion in Rats

¹ From the Division of Nutrition of the Departments of Biochemistry and Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee

Adult female albino Sprague-Dawley rats subjected to 500 r (backscatter) of whole-body x-irradiation exhibit an increase in the urinary excretion of the B₆ group of vitamins beginning on the 2nd day after irradiation. However, control animals, whose food intake was limited to that of the irradiated group, excreted amounts of vitamin B₆ that were quantitatively similar. It is concluded that the increase of vitamin B₆ excretion found after x-irradiation is a reflection of the irradiation-induced anorexia and is not due to tissue changes brought about by irradiation per se.

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